High-Mobility Group Box 1 Protein in Myocardial Infarction: Should it be Stimulated or Inhibited?
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چکیده
منابع مشابه
High-Mobility Group Box 1 Protein in Myocardial Infarction: Should it be Stimulated or Inhibited?
High-mobility group box 1 (HMGB1) protein was originally identified as a non-histone nuclear protein that stabilizes the nucleosome structure and regulates gene transcription 1). HMGB1 is highly conserved and ubiquitously expressed in the nucleus of almost all mammalian cells. In 1999, Wang et al. 2) reported that HMGB1 is released from activated macrophages, and extracellular HMGB1 acts as a l...
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High mobility group box 1 (HMGB1) is a nuclear protein released from necrotic cells, inducing inflammatory responses. Epidemiological studies suggested a possible association between periodontitis and cardiovascular diseases (CVDs). Due to tissue damage and necrosis of cardiac cells following myocardial infarction (MI), HMGB1 is released, activating an inflammatory reaction. However, it remains...
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High-mobility group box 1 protein (HMGB1), a member of highly conserved non-histone DNA binding protein family, has been studied as transcription factor and growth factor. Secreted extracellularly by activated monocytes and macrophages or passively released by necrotic or damaged cells, extracellular HMGB1 is a potent mediator of inflammation. Extracellular HMGB1 has apparently contrasting biol...
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ژورنال
عنوان ژورنال: Journal of Atherosclerosis and Thrombosis
سال: 2015
ISSN: 1340-3478,1880-3873
DOI: 10.5551/jat.ed008